Hjemmekampen mot Southend har blitt valgt ut som TV-kamp. Alle seriekampene kan fritt høres på nettradio via BBC Radio Humberside.
*BT Sport
| 17/07 | Cleethorpes | B | 4 | – | 1 | Trening | Fakta |
| 17/07 | Spalding Utd | B | 0 | – | 2 | Lincs Cup | Fakta |
| 20/07 | Mansfield Town | B | 1 | – | 0 | Trening | Fakta |
| 24/07 | Rotherham | H | 0 | – | 1 | Trening | Fakta |
| 30/07 | Hyde United | B | 0 | – | 2 | Trening | Fakta |
| 03/08 | Alfreton | B | 1 | – | 0 | Trening | Fakta |
| 07/08 | Boston | B | 1 | – | 0 | Trening | Fakta |
| 13/08 | Chesterfield | B | 1 | – | 2 | Trening | Fakta |
| 28/08 | Weymouth | H | 1 | – | 0 | Serie R2 | Fakta |
| 31/08 | Stockport | B | 0 | – | 0 | Serie R3 | Fakta |
| 04/09 | Barnet | H | 4 | – | 3 | Serie R4 | Fakta |
| 11/09 | Torquay | B | 3 | – | 1 | Serie R5 | Fakta |
| 14/09 | Wrexham | H | 3 | – | 1 | Serie R6 | Fakta |
| 18/09 | Eastleigh | H | 2 | – | 0 | Serie R7 | Fakta |
| 25/09 | Maidenhead | B | x | – | x | Serie R8 | 16:00 |
| 28/09 | Bromley | B | x | – | x | Serie R1 | 20:45 |
| 02/10 | Dover | H | x | – | x | Serie R9 | 16:00 |
| 05/10 | Altrincham | B | x | – | x | Serie R10 | 20:45 |
| 09/10 | Woking | B | x | – | x | Serie R11 | 16:00 |
| 23/10 | Yeovil | H | x | – | x | Serie R12 | 16:00 |
| 26/10 | Wealdstone | B | x | – | x | Serie R13 | 20:45 |
| 30/10 | Notts Co | H | x | – | x | Serie R14 | 16:00 |
| 13/11 | Aldershot | B | x | – | x | Serie R15 | 16:00 |
| 19/11 | Southend* | H | x | – | x | Serie R16 | 20:45 |
| 23/11 | Solihull Moors | B | x | – | x | Serie R17 | 20:45 |
| 27/11 | Boreham Wood | H | x | – | x | Serie R18 | 16:00 |
| 04/12 | Dagenham | B | x | – | x | Serie R19 | 16:00 |
| 11/12 | Chesterfield | H | x | – | x | Serie R20 | 16:00 |
| 26/12 | Halifax | B | x | – | x | Serie R21 | 13:30 |
| 28/12 | King’s Lynn Town | H | x | – | x | Serie R22 | 16:00 |
| 02/01 | Halifax | H | x | – | x | Serie R23 | 16:00 |
| 22/01 | Bromley | H | x | – | x | Serie R24 | 16:00 |
| 25/01 | Wrexham | B | x | – | x | Serie R25 | 20:45 |
| 29/01 | Wealdstone | H | x | – | x | Serie R26 | 16:00 |
| 05/02 | Notts Co | B | x | – | x | Serie R27 | 16:00 |
| 12/02 | Aldershot | H | x | – | x | Serie R28 | 16:00 |
| 18/02 | Southend | B | x | – | x | Serie R29 | 20:45 |
| 22/02 | Altrincham | H | x | – | x | Serie R30 | 20:45 |
| 26/02 | Dover | B | x | – | x | Serie R31 | 16:00 |
| 05/03 | Woking | H | x | – | x | Serie R32 | 16:00 |
| 12/03 | Yeovil | B | x | – | x | Serie R33 | 16:00 |
| 19/03 | Boreham Wood | B | x | – | x | Serie R34 | 16:00 |
| 22/03 | Solihull Moors | H | x | – | x | Serie R35 | 20:45 |
| 26/03 | Dagenham | H | x | – | x | Serie R36 | 16:00 |
| 02/04 | Chesterfield | B | x | – | x | Serie R37 | 16:00? |
| 09/04 | Weymouth | B | x | – | x | Serie R38 | 16:00 |
| 15/04 | Stockport | H | x | – | x | Serie R39 | 16:00 |
| 18/04 | King’s Lynn Town | B | x | – | x | Serie R40 | 16:00 |
| 23/04 | Torquay | H | x | – | x | Serie R41 | 16:00 |
| 30/04 | Barnet | B | x | – | x | Serie R42 | 16:00 |
| 07/05 | Maidenhead | H | x | – | x | Serie R43 | 16:00 |
| 15/05 | Eastleigh | B | x | – | x | Serie R44 | 16:00 |
Reservelaget
Reservelaget spiller i Central League.
15.09 Lincoln – Grimsby 15:00 (Central League Cup)
16.11 Rotherham – Grimsby 14:00 (Central League Cup)
05.01 Grimsby – Walsall 15:00 (Central League Cup)
02.02 Huddersfield – Grimsby 15:00 (Central League Cup)
Juniorlaget
14.07 Brigg Town A – Grimsby U18 4-3 (Trening)
17.07 Spalding A – Grimsby XI 2-0 (Lokal cup)
27.07 Norwich U18 – Grimsby U18 2-2 (Trening) Prøvespiller, Harvey Tomlinson
07.08.21 Grimsby – Mansfield 1-1 Edwin Essel
14.08.21 Doncaster – Grimsby 0-2 Jaz Goundry, Edwin Essel
21.08.21 Lincoln – Grimsby 2-2 Harvey Tomlinson, Callum Stratton (YAC)
28.08.21 Grimsby – Harrogate 2-1 Edwin Essel 2
02.09.21 Grimsby – Burton 2-0 Jaz Goundry, Callum Stratton
11.09.21 Rotherham – Grimsby 1-2
18.09.21 Grimsby – Scunthorpe 12:00
25.09.21 Grimsby – Scunthorpe 12:00 (YAC)
02.10.21 Lincoln – Grimsby 12:00
09.10.21 Rochdale – Grimsby 12:00 (YAC)
23.10.21 Huddersfield – Grimsby 12:00
30.10.21 Grimsby – Bradford 12:00
12.11.21 Burton – Grimsby 14:00
27.11.21 Grimsby – Doncaster 12:00
11.12.21 Harrogate – Grimsby 13:00
18.12.21 Grimsby – Rotherham 12:00
08.01.22 Mansfield – Grimsby 13:00
15.01.22 Scunthorpe – Grimsby 12:00
12.02.22 Lincoln – Grimsby 12:00
19.02.22 Grimsby – Huddersfield 12:00
12.03.22 Bradford – Grimsby 12:00
