Sesongen 2021-22 ledet til opprykk gjennom Play Off for Grimsby.
| 17/07 | Cleethorpes | B | 4 | – | 1 | Trening | Fakta |
| 17/07 | Spalding Utd | B | 0 | – | 2 | Lincs C | Fakta |
| 20/07 | Mansfield Town | B | 1 | – | 0 | Trening | Fakta |
| 24/07 | Rotherham | H | 0 | – | 1 | Trening | Fakta |
| 30/07 | Hyde United | B | 0 | – | 2 | Trening | Fakta |
| 03/08 | Alfreton | B | 1 | – | 0 | Trening | Fakta |
| 07/08 | Boston | B | 1 | – | 0 | Trening | Fakta |
| 13/08 | Chesterfield | B | 1 | – | 2 | Trening | Fakta |
| 28/08 | Weymouth | H | 1 | – | 0 | Serie | Fakta |
| 31/08 | Stockport | B | 0 | – | 0 | Serie | Fakta |
| 04/09 | Barnet | H | 4 | – | 3 | Serie | Fakta |
| 11/09 | Torquay | B | 3 | – | 1 | Serie | Fakta |
| 14/09 | Wrexham | H | 3 | – | 1 | Serie | Fakta |
| 18/09 | Eastleigh | H | 2 | – | 0 | Serie | Fakta |
| 25/09 | Maidenhead | B | 1 | – | 1 | Serie | Fakta |
| 28/09 | Bromley | B | 1 | – | 3 | Serie | Fakta |
| 02/10 | Dover | H | 6 | – | 0 | Serie | Fakta |
| 05/10 | Altrincham | B | 3 | – | 2 | Serie | Fakta |
| 09/10 | Woking | B | 1 | – | 0 | Serie | Fakta |
| 16/10 | Bromsgrove S¤ | B | 5 | – | 0 | FAC Q4 | Fakta |
| 23/10 | Yeovil | H | 2 | – | 0 | Serie | Fakta |
| 26/10 | Wealdstone | B | 0 | – | 1 | Serie | Fakta |
| 30/10 | Notts Co | H | 0 | – | 1 | Serie | Fakta |
| 06/11 | Kidderminister | B | 0 | – | 1 | FAC 1r | Fakta |
| 13/11 | Aldershot | B | 1 | – | 2 | Serie | Fakta |
| 19/11 | Southend* | H | 1 | – | 0 | Serie | Fakta |
| 23/11 | Solihull Moors | B | 0 | – | 2 | Serie | Fakta |
| 04/12 | Dagenham | B | 2 | – | 3 | Serie | Fakta |
| 11/12 | Chesterfield | H | 0 | – | 1 | Serie | Fakta |
| 18/12 | Stockport | B | 0 | – | 4 | FAT 3r | Fakta |
| 03/01 | Halifax* | H | 1 | – | 1 | Serie | Fakta |
| 11/01 | Halifax | B | 0 | – | 1 | Serie | Fakta |
| 15/01 | Altrincham | H | 2 | – | 0 | Serie | Fakta |
| 22/01 | Bromley | H | 1 | – | 2 | Serie | Fakta |
| 25/01 | Wrexham | B | 0 | – | 1 | Serie | Fakta |
| 29/01 | Wealdstone | H | 2 | – | 1 | Serie | Fakta |
| 05/02 | Notts Co | B | 2 | – | 1 | Serie | Fakta |
| 08/02 | King’s Lynn Town | H | 0 | – | 0 | Serie | Fakta |
| 12/02 | Aldershot | H | 3 | – | 1 | Serie | Fakta |
| 26/02 | Dover | B | 3 | – | 1 | Serie | Fakta |
| 05/03 | Woking | H | 1 | – | 0 | Serie | Fakta |
| 08/03 | Southend | B | 0 | – | 1 | Serie | Fakta |
| 12/03 | Yeovil | B | 2 | – | 0 | Serie | Fakta |
| 19/03 | Boreham Wood | B | 0 | – | 0 | Serie | Fakta |
| 22/03 | Solihull Moors | H | 1 | – | 2 | Serie | Fakta |
| 26/03 | Dagenham | H | 2 | – | 1 | Serie | Fakta |
| 02/04 | Chesterfield | B | 4 | – | 1 | Serie | Fakta |
| 09/04 | Weymouth | B | 0 | – | 0 | Serie | Fakta |
| 15/04 | Stockport | H | 1 | – | 0 | Serie | Fakta |
| 18/04 | King’s Lynn Town | B | 1 | – | 0 | Serie | Fakta |
| 23/04 | Torquay | H | 2 | – | 1 | Serie | Fakta |
| 30/04 | Barnet | B | 2 | – | 2 | Serie | Fakta |
| 07/05 | Maidenhead | H | 1 | – | 3 | Serie | Fakta |
| 10/05 | Boreham Wood | H | 1 | – | 0 | Serie | Fakta |
| 15/05 | Eastleigh | B | 4 | – | 4 | Serie | Fakta |
| 23/05 | Notts Co | B | 2 | – | 1 | P.Off Q | Fakta |
| 28/05 | Wrexham | B | 5 | – | 4 | P.Off S | Fakta |
| 05/06 | Solihull Moors | N | 2 | – | 1 | P.Off F | Fakta |
Reservelaget
Reservelaget spiller kun i Central League Cup. Disse kampene har vært vanskelige å arrangere.
21.09 Lincoln – Grimsby 1-0 (Central League Cup)
05.01 Grimsby – Walsall 6-1 (Central League Cup) Grant 2, Goundry, Sears, Bapaga, Tomlinson
02.02 Huddersfield – Grimsby 2-5 (Central League Cup) Scannell 2, Wright, Tomlinson, Essel
22.02 Rotherham – Grimsby 0-1 (Central League Cup)
Juniorlaget
14.07 Brigg Town A – Grimsby U18 4-3 (Trening)
17.07 Spalding A – Grimsby XI 2-0 (Lokal cup)
27.07 Norwich U18 – Grimsby U18 2-2 (Trening) Prøvespiller, Harvey Tomlinson
07.08.21 Grimsby – Mansfield 1-1 Edwin Essel
14.08.21 Doncaster – Grimsby 0-2 Jaz Goundry, Edwin Essel
21.08.21 Lincoln – Grimsby 2-2 Harvey Tomlinson, Callum Stratton (YAC)
28.08.21 Grimsby – Harrogate 2-1 Edwin Essel 2
02.09.21 Grimsby – Burton 2-0 Jaz Goundry, Callum Stratton
11.09.21 Rotherham – Grimsby 1-2
18.09.21 Grimsby – Scunthorpe 0-0
25.09.21 Grimsby – Scunthorpe (YAC) 3-1
28.09.21 Grimsby – Halifax 3-0 (FAC 2. kv runde) Harvey Tomlinson 2, Harry Milner
02.10.21 Lincoln – Grimsby 3-1
09.10.21 Rochdale – Grimsby 0-0 (YAC)
13.10.21 Chester – Grimsby 0-1 (FAC 3. kv runde) Edwin Essel
23.10.21 Huddersfield – Grimsby 0-8 Tomlinson 3, Branwell, Essel, Markham, Boyd, Khouri
26.10.21 Crewe – Grimsby (FAC) 3-0
30.10.21 Grimsby – Bradford 4-0
12.11.21 Burton – Grimsby 1-1 Essel
02.12.21 Grimsby – Blyth Spartans 2-0 (Ligacup 1r U19) Essel, Tomlinson
11.12.21 Harrogate – Grimsby 1-4 Milner 2, Essel, Sims
12.01.22 Solihull – Grimsby (Ligacup 2r U19) 2-2 (4-5 e.s) Milner, Tomlinson
15.01.22 Scunthorpe – Grimsby 2-2 Tomlinson 2
29.01.22 Grimsby – Rotherham 1-2
05.02.21 Grimsby – Doncaster 3-0
12.02.22 Grimsby – Lincoln 5-2 Tomlinson, Khouri, Braithwaite, Milner, Thorpe
16.02.22 Grimsby – South Shields (Ligacup 3r U19) 1-1 (4-5 e.s) Adlard
05.03.22 Mansfield – Grimsby 0-1
12.03.22 Bradford – Grimsby 0-0
19.03.22 Grimsby – Huddersfield 3-1 Tomlinson, Adlard, Milner
Grimsby avslutter sesongen med kamper i Merit League.
